Knee Osteoarthritis

Study to evaluate the analgesic efficacy of two dose levels of CNTX-XXXX, compared to placebo at 4 weeks, when administered as a single (AI) injection to the index knee in patients with knee Osteoarthritis with pain score 5-9.

Study to assess the efficacy and safety of XXXX-02 administered orally to subjects with knee osteoarthritis associated with bone marrow lesions